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Background: Leprosy is a chronic infectious disease that remains a public health problem in low- and middle-income countries. Household contacts of leprosy patients HHCs have increased risk of developing disease and are important links in the chain of transmission of Mycobacterium leprae. Based on epidemiological and operational factors, the global elimination strategy depends on the geographic stratification of endemic areas to intensify control activities.
The purpose of the study was to integrate epidemiological indicators and serology into the spatial and temporal analysis of M. Forty-nine percent of the contacts were seropositive to at least one of the immunological tests. Discussion: We observed substantial spatial heterogeneity of cases throughout the urban perimeter. Even so, four main clusters of patients and three main clusters of subclinical infection were identified.
Conclusions: Spatio-temporal epidemiology associated to serological assessment can identify high-risk areas imbedded within the overall epidemic municipality, to prioritize active search of new cases as well support prevention strategies in these locations of greater disease burden and transmission.
Such techniques should become increasingly useful and important in future action planning of health interventions, as decisions must be made to effectively allocate limited resources. Abstract Background: Leprosy is a chronic infectious disease that remains a public health problem in low- and middle-income countries. Substances Antibodies, Bacterial Antigens, Bacterial.